Agitation is a feeling of aggravation or restlessness brought on by provocation or in some cases, little to no provocation. It can be a sign of an underlying medical or psychiatric condition. Agitation can come on suddenly or over time. It can last for just a few minutes, or for weeks or even months. Pain, stress, and fever can all increase agitation. Agitation by itself may not be a sign of a health problem. However, if other symptoms occur, it can be a sign of disease. Agitation with a change in alertness (altered consciousness) can be a sign of delirium. Delirium has a medical cause and should be checked by a health care provider right away. There are many causes of agitation, some of which include: alcohol intoxication or withdrawal, allergic reaction, caffeine intoxication, certain forms of heart, lung, liver, or kidney disease, hyperthyroidism , nicotine withdrawal, poisoning (for example, carbon monoxide poisoning), theophylline, amphetamines, steroids, and certain other medicines, trauma, and vitamin B6 deficiency. Agitation can occur with brain and mental health disorders, such as anxiety, dementia, depression, mania and schizophrenia.